This tool for UE5 (5.3 and later) lets you automatically create instanced materials for many textures at once, given a base material with parameters to fill.

For example, if you have a folder full of textures called things like "Chair_BaseColor", "Chair_Normal", "Chair_Roughness", "Table_Albedo", "Table_NRM", "Table_Rough", you can, in one click, create the material instances "MI_Chair" and "MI_Table" with all the textures automatically in the right parameter slots. As long as your textures all have some suffix describing the content, this'll work.

You can also set the values for all Scalar, Vector and Static Switch parameters on your material instances.

Video how-to